High Protein Food with Similar Phosphorus Content as Lower Protein Foods Increases Levels of Uremic Toxins
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چکیده
منابع مشابه
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Protein-bound uremic toxins, indoxyl sulfate and p-cresol sulfate, increase oxidative stress and adversely affect chronic kidney disease progression and cardiovascular complications. In this study, we examined whether mitochondria are the target of indoxyl sulfate and p-cresol sulfate intoxication in vivo and in vitro. The kidneys of 10-week-old male B-6 mice with ½-nephrectomy treated with ind...
متن کاملProtein-Bound Uremic Toxins: New Insight from Clinical Studies
The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions. The present review focuses on a specific class of molecules, namely the family of protein-bound uremic toxins. Recent experimental studies hav...
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BACKGROUND Uremic toxins are emerging as important, non-traditional cardiovascular risk factors in chronic kidney disease (CKD). P-cresol has been defined as a prototype protein-bound uremic toxin. Conjugation of p-cresol creates p-cresylsulfate (PCS) as the main metabolite and p-cresylglucuronide (PCG), at a markedly lower concentration. The objective of the present study was to evaluate serum...
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ژورنال
عنوان ژورنال: Current Developments in Nutrition
سال: 2020
ISSN: 2475-2991
DOI: 10.1093/cdn/nzaa050_006